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Four chronological phases are described in cases of significant acute overdose: Under 24 hours Asymptomatic Mild nausea and vomiting 1 to 3 days Right upper quadrant tenderness Hepatotoxicity 3 to 4 days (severe cases) Fulminant hepatic failure and / or death Acidosis Renal failure Day 4 to 2 weeks Recovery Supportive care and monitoring General supportive care, such as IV fluid, anti-emetics, thromboembolic prophylaxis should be given as required on a case by case assessment

Glutathione is found in every cell of the human body and is the first line of defense against the most constant and damaging chemical fallout

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Phosphorylation of a triple-tyrosine cluster (Y1131/1135/1136) in the kinase domain of subunit can further amplify the kinase activity of IGF-IR